Autism BrainNet Newsletter

To learn about how the Autism BrainNet is contributing to understanding autism, please read the latest newsletter: Autism BrainNet Winter 2016 Newsletter


Autism BrainNet Webinar Series

We are happy to announce a new webinar series hosted by Autism BrainNet. The goal of this series is to educate the public on the challenges faced by parents with autism and how brain tissue research is addressing them.

 

October 14, 2016

Epilepsy and Autism Seen Through the Brain

On October 14th, Autism BrainNet hosted a webinar about research on the cellular changes associated with epilepsy in individuals with autism. Dr. Shefali Jeste of UCLA presented on the clinical features of individuals with a combination of epilepsy and autism, and Dr. David Menassa at Oxford University discussed alterations in glia cells in people with both epilepsy and autism. Glia, once thought to only be the support cells of the nervous system, are now known to work cooperatively with neurons that transmit information in the brain. A recording of the webinar can be viewed here.

 

December 13, 2016

What We Know about Autism because of Brain Tissue Research

On December 13, 2016, Dr. Matthew Anderson from Beth Isreal Deaconess Medical Center presented a 45 minute webinar on recent findings in autism thanks to studying the brains of people with autism.  It covers genetics, neuropathology and immunology.  It’s a great chance to hear a quick recap of findings from an Autism BrainNet node director.  Please click here to watch the 45 minute presentation and questions from the audience.


What Have Scientists Learned? What Do They Hope to Learn?

What have scientists learned about autism from brain tissue research and what do they hope to learn? Researchers learned that there are important cell differences in the brains of people with autism. For example, researchers have discovered that:

  • Children with autism have different underlying brain structures compared with typically developing children, including an overabundance of nerve cells in an area of the brain involved in social and communication skills.
  • Genes involved in cell connectivity tend to be expressed at lower levels in autism brains, and genes related to immune cells at higher levels, than in control brains.
  • The brains of autistic people have fewer oxytocin receptors than the brains of unaffected people. Oxytocin is a hormone that has an influence on social behavior.
  • There appear to be structural difference in the brains of people with autism, including differences in the number and size of neurons and the presence of inflammation.

Scientists hope to study the genetic functioning of brain cells and to understand the role of epigenetics (the modifying of gene behavior and the turning on and off of individual genes) in autism. They also need to study gene expression and changes specific to neurons, which can be seen only by examining brain tissue.

Brain research may also lead to the development of ways to influence the way the brain develops its connections in early childhood in order to reduce some of the difficulties experienced by people with autism. Scientists may also come to a better understanding of how brain structure relates to the special skills of some autistic people.


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